BPTES

Item no.	V1897-250mg
Manufacturer	InvivoChem LLC
CASRN	314045-39-1
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1897CAS #:314045-39-1Purity >=98% Description: BPTES is a potent and selective allosteric Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 uM. BPTES inhibits glutaminase activity expressed in human kidney cells with IC50 of 0.18 uM, and inhibits glutamate efflux by microglia with IC50 of 80-120 nM. BPTES preferentially slows cell growth in D54 cells with mutant IDH1. BPTES also inhibits glutaminase activity, lowers glutamate and alpha-KG levels, and increases glycolytic intermediates. BPTES (10 uM) inhibits cell growth of mHCC 3–4 cells derived from LAP/MYC tumors. BPTES also inhibits growth of a MYC-dependent P493 cells by blocking DNA replication, leading to cell death and fragmentation. References: Cancer Res. 2010 Nov 15; 70(22):8981-7; J Clin Invest. 2015 Jun; 125(6):2293-306.
Molecular Weight (MW)	524.68
Formula	C24H24N6O2S3
CAS No.	314045-39-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (190.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	O=C(NC1=NN=C(CCSCCC2=NN=C(NC(CC3=CC=CC=C3)=O)S2)S1)CC4=CC=CC=C4
Synonyms	N, N'-((thiobis(ethane-2, 1-diyl))bis(1, 3, 4-thiadiazole-5, 2-diyl))bis(2-phenylacetamide)

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Amount: 250 mg

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