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Lapaquistat acetate (TAK-475)

Lapaquistat acetate (TAK-475)

Item no.	V19020-5mg
Manufacturer	InvivoChem LLC
CASRN	189060-13-7
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 250 mg 25 mg 2 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V19020CAS #:189060-13-7Purity >=98% Description: Lapaquistat acetate, formerly known as TAK475, is a novel and potent squalene synthase inhibitor used as a cholesterol-lowering drug. As a squalene synthase inhibitor, Lapaquistat block the conversion of farnesyl diphosphate (FPP) to squalene.Lapaquistat acetate was originally designed for treating MevalonateKinase Deficiency (MKD), it is effective at lowering low-densitylipoprotein cholesterol, but it might cause liver damage. References: 1. SteinEA, et al. Lapaquistat acetate: development of a squalene synthaseinhibitor for the treatment of hypercholesterolemia. Circulation. 2011May 10; 123(18):1974-85. 2. MarcuzziA, et al. Repositioning of Tak-475 In Mevalonate Kinase Disease:Translating Theory Into Practice. Curr Med Chem. 2018; 25(24):2783-2796. Related CAS #: 189059-71-0 (free); 189060-13-7 (acetate) 189059-71-0 (free); 189060-13-7 (acetate)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 9/4/2025

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