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Dicoumarol (Dicumarol)

Dicoumarol (Dicumarol)

Item no.	V1911-2g
Manufacturer	InvivoChem LLC
CASRN	66-76-2
Amount	2 g
Quantity options	10 g 1 g 500 mg 50 g 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1911CAS #:66-76-2Purity >=98% Description: Dicoumarol (also named as Dicumarol) is an oral and competitive inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 uM, respectively. It is used as an anticoagulant by interfering with the metabolism of vitamin K. Dicoumarol is a naturally occurring anticoagulant that functions as a functional vitamin K depleter, similar to warfarin, a drug that dicoumarol inspired. It is also used in biochemical experiments as an inhibitor of reductases. Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. References: J Biol Chem. 2006 Dec 8; 281(49):37416-26; Clin Cancer Res. 2004 Jul 1; 10(13):4550-8.
Molecular Weight (MW)	336.29
Formula	C19H12O6
CAS No.	66-76-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (199.2 mM)
	Water: < 1 mg/mL
	Ethanol: 67 mg/mL (199.2 mM)
Other info	Chemical Name: 2H-1-Benzopyran-2-one, 3, 3'-methylenebis(4-hydroxy- InChi Key: DOBMPNYZJYQDGZ-UHFFFAOYSA-N InChi Code: InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8, 20-21H, 9H2 SMILES Code: O=C1C(CC2=C(O)C3=CC=CC=C3OC2=O)=C(O)C4=CC=CC=C4O1
Synonyms	NC-034; NSC-17860; NSC-221570; NSC-41834; NC 034; NSC 17860; NSC 221570; NSC 41834; NC034; NSC17860; NSC221570; NSC41834; Dicumarol; Dicumarol; Dicoumarol; Bishydroxycoumarin; Dicoumarin; Melitoxin; Antitrombosin

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