SF1670

Item no.	V1912-250mg
Manufacturer	InvivoChem LLC
CASRN	345630-40-2
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1912CAS #:345630-40-2Purity >=98% Description: SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 uM. SF1670 bound to the active site of PTEN and increased PtdIns(3, 4, 5)P3 signaling in neutrophils. In human neutrophils, SF1670 significantly increased Akt phosphorylation stimulated by chemoattractant and specifically increased PtdIns(3, 4, 5)P3 signaling. SF1670 efficiently increased Akt phosphorylation at the concentration of 250nM. In mouse neutrophils, SF1670 also increased Akt phosphorylation and PtdIns(3, 4, 5)P3 signaling, which was mediated by the inhibition of PTEN activity. References: Blood. 2011 Jun 16; 117(24):6702-13.
Molecular Weight (MW)	307.34
Formula	C19H17NO3
CAS No.	345630-40-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 29 mg/mL (94.4 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-(9, 10-dihydro-9, 10-dioxo-2-phenanthrenyl)-2, 2-dimethyl-propanamide InChi Key: VZQDDSYKVYARDW-UHFFFAOYSA-N InChi Code: InChI=1S/C19H17NO3/c1-19(2, 3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H, 1-3H3, (H, 20, 23) SMILES Code: CC(C)(C)C(NC(C=C1C2=O)=CC=C1C3=C(C2=O)C=CC=C3)=O
Synonyms	SF1670; SF-1670; SF 1670

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Amount: 250 mg

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