N6022

Item no.	V1914-250mg
Manufacturer	InvivoChem LLC
CASRN	1208315-24-5
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1914CAS #:1208315-24-5 Purity >=98% Description: N6022 is a selective, first-in-class and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Inhibition of GSNOR causes the accumulation of GSNO which acts as a vasodilator and anti-inflammatory factor. N6022 presents an IC50 value of 8nM in the GSNO reduction assay and 32nM in the HMGSH oxidation assay. The Ki values are 2.5nM and 3.1nM, respectively. N6022 is selective against GSNOR over other human ADH enzymes. The IC50 values are 21uM, 67uM and 0.5uM for ADH IB, ADH II and ADH IV, respectively. References: Biochemistry. 2012 Mar 13; 51(10):2157-68; ACS Med Chem Lett. 2011 Mar 11; 2(5):402-6.
Molecular Weight (MW)	414.46
Formula	C24H22N4O3
CAS No.	1208315-24-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 82 mg/mL (197.8 mM)
	Water: < 1 mg/mL
	Ethanol: 5 mg/mL (12.1 mM)
Other info	Chemical Name: 3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid InChi Key: YVPGZQLRPAGKLA-UHFFFAOYSA-N InChi Code: InChI=1S/C24H22N4O3/c1-16-14-18(24(25)31)4-9-21(16)28-20(8-11-23(29)30)7-10-22(28)17-2-5-19(6-3-17)27-13-12-26-15-27/h2-7, 9-10, 12-15H, 8, 11H2, 1H3, (H2, 25, 31)(H, 29, 30) SMILES Code: O=C(O)CCC1=CC=C(C2=CC=C(N3C=CN=C3)C=C2)N1C4=CC=C(C(N)=O)C=C4C
Synonyms	N6022; N-6022; N 6022

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Amount: 250 mg

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