MI-2 (MALT1 inhibitor)

Description: MI-2 (also known as MALT1 inhibitor) is a potent and irreversible MALT1 inhibitor with IC50 of 5.84 uM, and binds directly to MALT1, irreversibly suppresses protease function. MI-2 inhibits MALT1 functions in ABC-DLBCL cell lines with excellent cell penetration. MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-kappaB activity induced by MALT1. MI-2 produces selective growth inhibition for MALT1-dependent cell lines with GI50 of 0.2, 0.5, 0.4, and 0.4 uM in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, whereas the ABC-DLBCL MALT1-independent cell lines, U2932 and HLY-1, and the two GCB-DLBCL cell lines were resistant.

References: Cancer Cell. 2012 Dec 11; 22(6):812-24.