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PTC-209 HBr

PTC-209 HBr

Item no.	V1932-50mg
Manufacturer	InvivoChem LLC
CASRN	1217022-63-3
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1932CAS #:1217022-63-3 Purity >=98% Description: PTC-209 HBr is the hydrobromide salt of PTC-209. PTC-209 is a novel, potent and selective BMI-1 inhibitor with IC50 of 0.5 uM and with potential anticancer activity. It can lead to irreversible reduction of cancer-initiating cells (CICs). PTC-209 inhibited both UTR-mediated reporter expression and endogenous BMI-1 expression in HCT116 (human colorectal cell) and HT1080 (human fibrosarcoma tumor cell) in a dose dependent manner. In addition, the inhibitory effect of PTC-209 was not from its cytotoxicity. PTC-209 also specifically reduced PRC1 activity. References: Nat Med. 2014 Jan; 20(1):29-36. Related CAS#: 315704-66-6 (free base)
Molecular Weight (MW)	576.10
Formula	C17H13Br2N5OS.HBr
CAS No.	1217022-63-3 (HBr);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (173.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-(2, 6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1, 2-a]pyrimidin-3-yl)-2-thiazolamine hydrobromide InChi Key: UOPFJYYKFDZXSY-UHFFFAOYSA-N InChi Code: InChI=1S/C17H13Br2N5OS.BrH/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19; /h3-8H, 1-2H3, (H, 22, 23); 1H SMILES Code: CC1=C(C2=CSC(NC3=C(Br)C=C(OC)C=C3Br)=N2)N4C=CC=NC4=N1.[H]Br
Synonyms	PTC-209; PTC 209; PTC209 Hydrobromide

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Amount: 50 mg

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