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AdipoRon (SC-396658)

AdipoRon (SC-396658)

Item no.	V1956-500mg
Manufacturer	InvivoChem LLC
CASRN	924416-43-3
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1956CAS #:924416-43-3 Purity >=98% Description: AdipoRon (also known as SC-396658) is a novel, first-in-class, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 uM for AdipoR1 and AdipoR2, respectively. AdipoRon (5-50 uM) increased AMPK phosphorylation via AdipoR1 in a dose-dependent way. Also, AdipoRon replenished adiponectin-stimulated AMPK phosphorylation. In C2C12 myotubes, AdipoRon increased PGC-1alpha expression and mitochondrial DNA content in a Ca2+- and dose-dependent way. References: Nature. 2013 Nov 28; 503(7477):493-9.
Molecular Weight (MW)	428.52
Formula	C27H28N2O3
CAS No.	924416-43-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 86 mg/mL (200.7 mM)
	Water: < 1 mg/mL
	Ethanol: 50 mg/mL (116.7 mM)
Other info	Chemical Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide InChi Key: SHHUPGSHGSNPDB-UHFFFAOYSA-N InChi Code: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14, 24H, 15-20H2, (H, 28, 30) SMILES Code: O=C(C1=CC=C(OCC(NC2CCN(CC3=CC=CC=C3)CC2)=O)C=C1)C4=CC=CC=C4
Synonyms	SC-396658; SC396658; SC 396658;

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Amount: 500 mg

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