Visomitin (SKQ-1)

Description: Visomitin (SKQ1; plastoquinonyl decyltriphenyl phosphonium; PDTP) is a higly potent mitochondria-targeted antioxidant with excellent mitochondrion membrane penetrating ability. SKQ1 is also an API for making eye drop drug called Visomitin. SKQ1 showed activities (1) to prevent amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices; (2) to reverse aging-related biomarkers in rats; (3) to slow down the development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats; (4) to increase the lifespan of male rodents under LP or SPF conditions. SKQ1 can penetrate cell membranes , and is proposed as an anti-aging treatment. Visomitin, which API is SKQ1, is currently under clinical trials for treating glaucoma in Russia. For the convenience of use, SKQ1 is supplied as solution of 200mg / mL in ethanol-water (1:1, v/v).

References: Samuilov VD, Kiselevsky DB. Effect of Cationic Plastoquinone SkQ1 on Electron Transfer Reactions in Chloroplasts and Mitochondria from Pea Seedlings. Biochemistry (Mosc). 2015 Apr; 80(4):417-23. doi: 10.1134/S0006297915040045. PubMed PMID: 25869358.

Related CAS #: 934826-68-3 (bromide) 1372443-45-2 (chloride) 1372443-48-5 (sulfate) 934960-96-0 (cation) 714085-40-1 (iodide)