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Dexrazoxane xHCl (ICRF-187)

Dexrazoxane xHCl (ICRF-187)

Item no.	V2005-10g
Manufacturer	InvivoChem LLC
CASRN	149003-01-0
Amount	10 g
Quantity options	100 mg 1 g 250 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2005CAS #:149003-01-0 Purity >=98% Description: Dexrazoxane xHCl (formerly also known as ICRF-187, ADR-529) acts as an intracellular iron chelator, which decreases the formation of superoxide radicals, and is mainly used as a cardioprotective agent. As a derivative of EDTA, dexrazoxane chelates iron, but the precise mechanism by which it protects the heart is not known. This agent is used to protect the heart against the cardiotoxic side effects. Dexrazoxane (10 mM), known clinically to limit anthracycline cardiac toxicity, prevents daunorubicin-induced myocyte apoptosis, but not necrosis induced by higher anthracycline concentrations in rat cardiac myocytes. References: Circ Res. 1999 Feb 19; 84(3):257-65; Cancer Res. 2007 Sep 15; 67(18):8839-46. Related CAS#: 1263283-43-7 (HCl); 24584-09-6 (free base)
Molecular Weight (MW)	N/A
Formula	C11H16N4O4.xHCl
CAS No.	149003-01-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (196.9 mM)
	Water: 60 mg/mL (196.9 mM)
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 2, 6-Piperazinedione, 4, 4'-((1S)-1-methyl-1, 2-ethanediyl)bis-, hydrochloride (1:1) InChi Key: BIFMNMPSIYHKDN-FJXQXJEOSA-N InChi Code: 1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14; /h7H, 2-6H2, 1H3, (H, 12, 16, 17)(H, 13, 18, 19); 1H/t7-; /m0./s1 SMILES Code: Cl.C[CH](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
Synonyms	ICRF-187 (ADR-529) HCl; (+)-Razoxane hydrochloride, ADR-529 hydrochloride, Cardioxan, Dexrazoxane HCl, Dexrazoxane hydrochloride, ICRF-187 hydrochloride, Savene; ADR529; ADR-529; ADR 529; ICRF-187; ICRF187; ICRF 187; NSC169780; NSC-169780; NSC 169780; Cardioxan; Cardioxane; US brand names: Totect; Zinecard. Foreign brand names: Cardioxane Savene.

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Amount: 10 g

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