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Description: Dotinurad (FYU-981) is a novel, potent and selective urate reabsorption inhibitor (SURI) approved in Japan for treatment of hyperuricemia and gout. It has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1) with an IC50 of 3.6 uM for uric acid.
References: Eur J Med Chem. 2019 Mar 15; 166:186-196.; Drug Metab Pharmacokinet. 2020 Mar 9. pii: S1347-4367(20)30018-5.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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