Biapenem (CLI 86815)

Description: Biapenem (also called L-627, CLI 86815, LJC10627) is a potent carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains. Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates.

References: Antimicrob Agents Chemother. 1994 Apr; 38(4):889-93; Jpn J Antibiot. 2003 Apr; 56(2):138-41; J Infect Chemother. 2012 Aug; 18(4):472-8.