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Alfacalcidol (1-hydroxycholecalciferol)

Alfacalcidol (1-hydroxycholecalciferol)

Item no.	V2037-50mg
Manufacturer	InvivoChem LLC
CASRN	41294-56-8
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2037CAS #:41294-56-8 Purity >=98% Description: Alfacalcidol (1-hydroxycholecalciferol), an active metabolite of Vitamin D, is a potent and non-selective VDR activator medication that has been widely used in the treatment of osteoporosis. Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland. In addition, in a high bone-turnover state after OVX, Alfacalcidol has been reported to inhibit osteoclastic bone resorption at pharmacological doses that do not cause hypercalcemia. Apart from these, Alfacalcidol has shown the stimulative effect to the bone formation. Furthermore, Alfacalcidol has been found to enhance bone mass and bone strength at given serum and urinary calcium levels in the OVX model. References: J Bone Miner Res. 2000 Apr; 15(4):770-9.; Calcif Tissue Int. 1999 Oct; 65(4):311-6. Related CAS#: 1641940-94-4 (Alfacalcidol-D6, a deuterated Alfacalcidol); 82266-85-1 (Impurity of Alfacalcidol)
Molecular Weight (MW)	400.64
Formula	C27H44O2
CAS No.	41294-56-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 80 mg/mL (199.7 mM)
	Water: < 1 mg/mL
	Ethanol: 80 mg/mL (199.7 mM)
Other info	Chemical Name: (1R, 3S, 5Z)-5-[(2E)-2-[(1R, 3aS, 7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2, 3, 3a, 5, 6, 7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1, 3-diol InChi Key: OFHCOWSQAMBJIW-DWKIUPLPSA-N InChi Code: InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24, 25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12, 18-19, 23-26, 28-29H, 4, 6-10, 13-17H2, 1-3, 5H3/b21-11+, 22-12- SMILES Code: CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Synonyms	1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3

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Amount: 50 mg

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