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bms-433796

bms-433796

Item no.	V2060-250mg
Manufacturer	InvivoChem LLC
CASRN	935525-13-6
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2060CAS #:935525-13-6 Purity >=98% Description: BMS 433796 is a novel and potent gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. BMS-433796 exhibited favorable pharmacodynamic and pharmacokinetic profiles. Chronic dosing of BMS-433796 in Tg2576 mice suggested a narrow therapeutic window and Notch-mediated toxicity at higher doses. Reduction of brain beta-amyloid peptide (Abeta) synthesis by gamma-secretase inhibitors is a promising approach for the treatment of Alzheimer's disease. References: Bioorg Med Chem Lett. 2007 Jul 15; 17(14):4006-11.; J Pharmacol Exp Ther. 2007 Oct; 323(1):102-8.
	Name: BMS-433796 CAS#: 935525-13-6 Chemical Formula: C21H20F2N4O4 Exact Mass: 430.14526 Molecular Weight: 430.4 Elemental Analysis: C, 58.60; H, 4.68; F, 8.83; N, 13.02; O, 14.87
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BMS433796; BMS-433796; BMS 433796. Chemical Name: (S)-2-((S)-2-(3, 5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-3-methyl-4-oxo-4, 5-dihydro-3H-benzo[d][1, 2]diazepin-5-yl)propanamide InChi Key: HXEHCCYOTHDPPI-NBHSMZAVSA-N InChi Code: InChI=1S/C21H20F2N4O4/c1-11(25-20(30)18(28)13-7-14(22)9-15(23)8-13)19(29)26-17-16-6-4-3-5-12(16)10-24-27(2)21(17)31/h3-11, 17-18, 28H, 1-2H3, (H, 25, 30)(H, 26, 29)/t11-, 17-, 18-/m0/s1 SMILES Code: C[CH](NC([CH](C1=CC(F)=CC(F)=C1)O)=O)C(N[CH]2C3=CC=CC=C3C=NN(C)C2=O)=O

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Amount: 250 mg

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Delivery expected until 9/4/2025

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