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Description: WIN 55, 212-2 Mesylate is a novel and potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. WIN 55212-2 impairs contextual fear conditioning through the activation of CB1 cannabinoid receptors. Win 55212-2 attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. WIN 55212-2 inhibits neurogenic inflammations in airway tissues.
References: Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3; 57:140-5
Related CAS#: 131543-22-1 (free base)
CAS#: 131543-23-2(mesylate);
Chemical Formula: C28H30N2O6S
Chemical Name: [(3R)-2, 3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1, 2, 3-de]-1, 4-benzoxazin-6-yl]-1-naphthalenyl-methanone, monomethanesulfonate;
SMILES Code: O=C(C1=C(C)N2[CH](CN3CCOCC3)COC4=CC=CC1=C24)C5=C6C=CC=CC6=CC=C5.CS(=O)(O)=O
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