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GSK1379725A

GSK1379725A

Item no.	V2062-50mg
Manufacturer	InvivoChem LLC
CASRN	1802251-00-8
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2062CAS #:1802251-00-8Purity >=98% Description: GSK1379725A (AU1) is the first small molecule selective for BPTF over Brd4, as an inhibitor of Brd4 and a selective BPTF ligand with Kd of 2.8 uM. AU1 is active in a cell-based reporter assay. No binding is detected with Brd4. Three new Brd4 inhibitors with submicromolar affinity were also discovered. Brd4 hits were validated in a thermal stability assay and potency determined via fluorescence anisotropy. The speed, ease of interpretation, and low protein concentration needed for protein-observed (19)F NMR experiments in a multiprotein format offers a new method to discover and characterize selective ligands for bromodomain-containing proteins. References: ACS Chem Biol. 2015 Oct 16; 10(10):2246-56.
	Name: GSK1379725A CAS#: 1802251-00-8 Chemical Formula: C23H23FN6O3 Exact Mass: 450.1816 Molecular Weight: 450.47 Elemental Analysis: C, 61.32; H, 5.15; F, 4.22; N, 18.66; O, 10.65
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AU1; AU-1; AU 1; GSK1379725A; GSK 1379725 A; GSK-1379725-A; Chemical Name: 3-(3-{1-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-pyrrolidin-3-yl}-ureido)-benzoic acid methyl ester InChi Key: LLVPDBRSUHNJQQ-UHFFFAOYSA-N InChi Code: InChI=1S/C23H23FN6O3/c1-33-21(31)15-3-2-4-18(13-15)27-23(32)28-19-10-12-30(14-19)20-9-11-25-22(29-20)26-17-7-5-16(24)6-8-17/h2-9, 11, 13, 19H, 10, 12, 14H2, 1H3, (H, 25, 26, 29)(H2, 27, 28, 32) SMILES Code: O=C(OC)C1=CC=CC(NC(NC2CN(C3=NC(NC4=CC=C(F)C=C4)=NC=C3)CC2)=O)=C1

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Amount: 50 mg

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Delivery expected until 9/4/2025

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