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azeliragon-hcl

azeliragon-hcl

Item no.	V2094-500mg
Manufacturer	InvivoChem LLC
CASRN	1284150-65-7
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2094CAS #:1284150-65-7Purity >=98% Description: Azeliragon 2HCl (also known as TTP488 2HCl and PF-04494700 2HCl) is a potent and orally bioactive RAGE (Receptor for Advanced Glycation End products) inhibitor that has the potential for the treatment of mild-to-moderate Alzheimer's disease and cerebral amyloid angiopathy. RAGE is a pattern recognition receptor that affects the movement of amyloid (a biomarker for Alzheimer's disease) into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon has been shown to be involved in adaptive immune responses. It is currently in Phase 3 clinical trial. References: BMC Neurol. 2014 Jan 15; 14:12; Front Aging Neurosci. 2014 Oct 20; 6:290. Related CAS#: 603148-36-3 (free base); 1284150-65-7 (2HCl)
Molecular Weight (MW)	605.14
Formula	C32H40Cl3N3O2
CAS No.	1284150-65-7 (2HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1 mg/mL
	Ethanol: N/A
SMILES Code	CCN(CC)CCCOC1=CC=C(C2=CN(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)C(CCCC)=N2)C=C1.[H]Cl.[H]Cl
Synonyms	PF-04494700 2HCl; PF 04494700 2HCl; PF04494700 2HCl; Azeliragon 2HCl; TTP488 2HCl; TTP-488 2HCl; TTP 488 2HCl; PF-04494700 diHCl; PF 04494700 diHCl; PF04494700 diHCl; Azeliragon diHCl; TTP488 diHCl; TTP-488 diHCl; TTP 488 diHCl; TTP488 dihydrochloride; TTP-488 dihydrochloride; TTP 488 dihydrochloride; PF-04494700 dihydrochloride; PF 04494700 dihydrochloride; PF04494700 dihydrochloride; Azeliragon dihydrochloride

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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Delivery expected until 9/4/2025

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