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Description: CAY10566 is a novel, orally bioavailable and selective SCD1 (stearoyl-CoA desaturase 1) inhibitor with IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. Cancer cell growth requires fatty acids to replicate cellular membranes. The kinase Akt is known to up-regulate fatty acid synthesis and desaturation, which is carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.
References: Proc Natl Acad Sci U S A. 2013 May 28; 110(22):8882-7; J Lipid Res. 2012 Aug; 53(8):1543-52.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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