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Zileuton (A 64077; Abbott 64077)

Zileuton (A 64077; Abbott 64077)

Item no.	V2108-25mg
Manufacturer	InvivoChem LLC
CASRN	111406-87-2
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2108CAS #:111406-87-2 Purity >=98% Description: Zileuton (also known as A-64077; Abbott 64077; ZYFLO; ZYFLO CR) is a novel, potent and orally bioactive inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, it was introduced in 1996 to decrease the symptoms of asthma. Zileuton suppresses PG biosynthesis by interference with arachidonic acid (AA) release in macrophages. Zileuton significantly reduces PGE2 and 6-keto prostaglandin F1alpha (PGF1alpha) levels in activated mouse peritoneal macrophages and in J774 macrophages. Zileuton inhibits PGE2 production in LPS-stimulated human whole blood and suppresses PGE2 and 6-keto PGF1alpha pleural levels in rat carrageenan-induced pleurisy. References: Br J Pharmacol. 2010 Oct; 161(3):555-70; Gut. 1996 Jun; 38(6):899-904; Br J Pharmacol. 2008 Feb; 153(3):568-82. Related CAS#: 118569-21-4 (Zileuton sodium); 111406-87-2 (free)
Molecular Weight (MW)	236.29
Formula	C11H12N2O2S
CAS No.	111406-87-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 47 mg/mL (198.9 mM)
	Water: < 1 mg/mL
	Ethanol: 47 mg/mL (198.9 mM)
Other info	Chemical Name: 1-(1-(benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea InChi Key: MWLSOWXNZPKENC-UHFFFAOYSA-N InChi Code: InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7, 15H, 1H3, (H2, 12, 14) SMILES Code: O=C(N)N(C(C1=CC2=CC=CC=C2S1)C)O
Synonyms	A64077; A-64077; A64077; A 64077; trade name ZYFLO; ZYFLO CR.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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