Carbidopa

Description: Carbidopa (also known as MK485, MK-485; trade name: Lodosyn; abbreviated as CD), a potent and competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine. CD premedication improves 11C-5-HTP PET image quality and facilitates detection of NET lesions. Because of the similarity of metabolic pathways, this method could probably be applied to improve PET imaging using other tracers like 18F-DOPA and 11C-DOPA. Carbidopa (100 microM) decreased growth of (but did not kill) SK-N-SH neuroblastoma and A204 rhabdomyosarcoma cells and did not affect proliferation of DU 145 prostate, MCF7 breast, or NCI-H460 large cell lung carcinoma lines. sublethal doses of carbidopa produced additive cytotoxic effects in carcinoid cells in combination with etoposide and cytotoxic synergy in SCLC cells when coincubated with topotecan.

References: J Clin Pharmacol. 2000 Aug; 40(8):854-60; Eur J Nucl Med Mol Imaging. 2006 Jan; 33(1):60-5; Clin Cancer Res. 2000 Nov; 6(11):4365-72.

Related CAS#: 38821-49-7 (hydrate); 1907685-81-7 (Foscarbidopa, Carbidopa 4?-monophosphate)