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gne-5729

gne-5729

Item no.	V2130-25mg
Manufacturer	InvivoChem LLC
CASRN	2026635-66-3
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2130CAS #:2026635-66-3 Purity >=98% Description: GNE 5729 is a novel, potent, brain permeable positive allosteric modulator (PAM) and GluN2A subunit-selective of NMDAR with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 uM for GluN2C and GluN2D, respectively. The N-methyl-d-aspartate receptor (NMDAR) is an ionotropic glutamate receptor, gated by the endogenous coagonists glutamate and glycine, permeable to Ca2+ and Na+. NMDAR dysfunction is associated with numerous neurological and psychiatric disorders, including schizophrenia, depression, and Alzheimer's disease. GNE-0723 is a and brain-penetrant positive allosteric modulatorof NMDARs. References: ACS Med Chem Lett. 2016 Oct 31; 8(1):84-89.
	Name: GNE-5729 CAS#: 2026635-66-3 Chemical Formula: C17H10Cl2F3N5O Exact Mass: 427.0214 Molecular Weight: 428.1962 Elemental Analysis: C, 47.69; H, 2.35; Cl, 16.56; F, 13.31; N, 16.36; O, 3.74
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GNE-5729; GNE 5729; GNE5729. Chemical Name: (1R, 2R)-2-(7-chloro-2-((5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-4-oxo-4H-pyrido[1, 2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile InChi Key: GPMGDUIAVSFGGH-WCBMZHEXSA-N InChi Code: InChI=1S/C17H10Cl2F3N5O/c18-11-1-2-14-24-9(7-26-13(19)5-12(25-26)17(20, 21)22)4-15(28)27(14)16(11)10-3-8(10)6-23/h1-2, 4-5, 8, 10H, 3, 7H2/t8-, 10+/m0/s1 SMILES Code: ClC(C=C1)=C([CH]2[CH](C2)C#N)N3C1=NC(CN4C(Cl)=CC(C(F)(F)F)=N4)=CC3=O

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Amount: 25 mg

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Delivery expected until 10/2/2025

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