Garcinone D

Description: Garcinone D is a naturally occuring xanthone isolated from mangosteen, acting as an inhibitor of NF-kappaB p65 and p50 activation, exhibiting cytotoxicity against several cancer cell lines. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners.

References: GarcinoneD, a natural xanthone promotes C17.2 neural stem cell proliferation:Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway.Neurosci Lett. 2016 Jul 28; 626:6-12.; Leewanich P, Suksamram S. Xanthones Isolated from the Pericarp of Mangosteen Inhibit Neurotransmitter Receptors Expressed in Xenopus Oocytes. J Med Assoc Thai. 2015 Nov; 98 Suppl 10:S118-23. PubMed PMID: 27276843.