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APX-115

APX-115

Item no.	V2231-10mg
Manufacturer	InvivoChem LLC
CASRN	1270084-92-8
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2231CAS #:1270084-92-8Purity >=98% Description: APX-115, also known as EWHA 18278, is a novel, potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 uM, 0.57 uM, and 0.63 uM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.APX-115 protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice. APX-115 might be a promising therapeutic agent for the treatment of DN because of its pan-NOX inhibitory activity, including its NOX5 inhibitory activity, and also owing to its anti-inflammatory effect.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 9/4/2025

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