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Description: IQ-1S is a potent and selective c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis.
References: Atochin DN, Schepetkin IA, Khlebnikov AI, Seledtsov VI, Swanson H, Quinn MT, Huang PL. A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitorprotects against cerebral ischemia-reperfusion injury in mice. Neurosci Lett.2016 Apr 8; 618:45-9. doi: 10.1016/j.neulet.2016.02.033. Epub 2016 Feb 26. PubMedPMID: 26923672.
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