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Description: IWP-4 is a potent inhibitor of Wnt/beta-catenin signaling.
References: Garcia-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and related compounds as selective ATP-competitive inhibitors of Casein Kinase 1 (CK1) delta/epsilon. J Med Chem. 2018 Apr 9. doi: 10.1021/acs.jmedchem.8b00095. Epub ahead of print PubMed PMID: 29630366.
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