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10-Deacetylbaccatin-III (10-DAB)

10-Deacetylbaccatin-III (10-DAB)

Item no.	V2324-50mg
Manufacturer	InvivoChem LLC
CASRN	32981-86-5
Amount	50 mg
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2324CAS #:32981-86-5 Purity >=98% Description: 10-Deacetylbaccatin-III (also known as 10-DAB, 10-Deacetylbaccatin) is an intermediate with anticancer activities. is It is used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus. Due to the low availability of taxol from its natural sources, 10-DAB is used as a raw material for the preparation of taxol and its derivatives. Being easily extracted from the annual cute of the yew leaves, 10-DAB has a very folded chemical structure with the alpha hydroxyl group hindered at C-13 easily to form a hydrogen bond with the 4alpha acetyl group. References: Plant Biol (Stuttg). 2013 Jan; 15(1):19-26; Tetrahedron 1986; 42(16): 4451-4460; Phytother Res. 2012 Apr; 26(4):552-6.
Molecular Weight (MW)	544.59
Formula	C29H36O10
CAS No.	32981-86-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 109 mg/mL (200.2 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS)-12b-acetoxy-4, 6, 9, 11-tetrahydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-1H-7, 11-methanocyclodeca[3, 4]benzo[1, 2-b]oxet-12-yl benzoate InChi Key: YWLXLRUDGLRYDR-ZHPRIASZSA-N InChi Code: InChI=1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5, 23(34)21(33)20(14)26(29, 3)4)18(32)11-19-28(22, 13-37-19)39-15(2)30/h6-10, 17-19, 21-22, 24, 31-33, 36H, 11-13H2, 1-5H3/t17-, 18-, 19+, 21+, 22-, 24-, 27+, 28-, 29+/m0/s1 SMILES Code: O=C(O[CH]([C]1([H])[C]2(C)[CH](O)C[C]3([H])OC[C]31OC(C)=O)[C]4(O)C[CH](O)C(C)=C(C4(C)C)[CH](O)C2=O)C5=CC=CC=C5
Synonyms	10DAB; 10DAB III

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Amount: 50 mg

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