20-Hydroxyecdysone (Crustecdysone)

Description: 20-Hydroxyecdysone (also known as B-ecdysone, Crustecdysone, Commisterone Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. In H4IIE cell culture, 20-Hydroxyecdysone treatment decreases expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), reduces glucose production, and induces Akt2 phosphorylation sensitive to the phosphoinositide-3 kinase pathway-specific inhibitor LY-294002. 20-Hydroxyecdysone treatment before or after CoCl2 exposure significantly ameliorates CoCl2-induced cellular injuries.

References: Arch Insect Biochem Physiol. 2012 Apr; 79(4-5):207-19; J Cell Biochem. 2010 Dec 15; 111(6):1512-21; Am J Physiol Endocrinol Metab. 2009 Mar; 296(3):E433-9.