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PD0166285

PD0166285

Item no.	V2564-25mg
Manufacturer	InvivoChem LLC
CASRN	185039-89-8
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2564CAS #:185039-89-8 Purity >=98% Description: PD0166285 is a novel and potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50s of 24 and 72 nM for WEE1 and Myt1, respectively). PD0166285 is a novel G2 checkpoint abrogator. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line. References: Cancer Res. 2001; 61(22):8211-7; BMC Cancer. 2006; 6:292; Cancer Cell. 2010; 18(3):244-57.
Molecular Weight (MW)	512.43
Formula	C26H27Cl2N5O2
CAS No.	185039-89-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (195.1 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (195.1 mM)
Other info	Chemical Name: 6-(2, 6-dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2, 3-d]pyrimidin-7(8H)-one InChi Key: IFPPYSWJNWHOLQ-UHFFFAOYSA-N InChi Code: InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12, 15-16H, 4-5, 13-14H2, 1-3H3, (H, 29, 30, 31) SMILES Code: O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=C(OCCN(CC)CC)C=C4)N=C3N1C
Synonyms	PD0166285; PD 0166285; PD0166285; PD166285; PD 166285; PD166285

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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