BGP-15

Item no.	V2569-100mg
Manufacturer	InvivoChem LLC
CASRN	66611-38-9
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2569CAS #:66611-38-9Purity >=98% Description: BGP-15 is a potent PARP inhibitor that can protect against heart failure and atrial fibrillation in mice. BGP-15 (200 uM) prevents the imatinib mesylate-induced oxidative damages, attenuates the depletion of high-energy phosphates, alters the signaling effect of imatinib mesylate by preventing p38 MAP kinase and JNK activation, and induced the phosphorylation of Akt and GSK-3beta. In-vivo study indicated that BGP-15 improved cardiac function and reduced arrhythmic episodes in two HF and AF mouse models. In these models, BGP-15 was associated with increased phosphorylation of IGF1R. Description: References: Am J Pathol. 2016; 186:3246-3260; Sci Transl Med. 2016; 8(350):350ra103; Nat Commun. 2014; 5:5705. References: Related CAS #: 66611-37-8 (HCl) 66611-38-9 (free base)
Molecular Weight (MW)	351.27
Formula	C14H24Cl2N4O2
CAS No.	66611-37-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 11.33 mg/mL
	Water: N/A
	Ethanol: N/A
Other info	Chemical Name: N-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide SMILES Code: N=C(NOCC(O)CN1CCCCC1)C2=CN=CC=C2
Synonyms	BGP15; BGP-15; BGP 15; BGP15 hydrochloride; BGP15 HCl; N-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide dihydrochloride

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Amount: 100 mg

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