« Back
Home /
ly333531

ly333531

Item no.	V2574-250mg
Manufacturer	InvivoChem LLC
CASRN	169939-93-9
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2574CAS #:169939-93-9 Purity >=98% Description: Ruboxistaurin hydrochloride (LY333531) is a novel, potent and specific inhibitor of PKCbeta (protein kinase C). It competitively and reversibly inhibits PKCbeta1 and PKCbeta2 with IC50 values of 4.7 and 5.9 nM respectively. It has the usefulness to treat diabetic nephropathy and diabetic macular edem. LY333531 strikingly decreases the chance of HUVEC survival and the effect of LY333531 on apoptotic cell death in HUVEC significantly increases compared with the AGEs group. Blockade of PKC-beta up-regulates the expression of Bax and Bad proteins and down-regulates the expression of Bcl-2 protein. Moreover, LY333531 reduces the ratio of Bcl-2/Bax. References: J Med Chem. 1996 Jul 5; 39(14):2664-71; Diabetes. 2013 Jul; 62(7):2318-28; Pharmazie. 2011 Nov; 66(11):881-7. Related CAS#: 169939-94-0 (free base); 202260-21-7 (mesylate hydrate); 192050-59-2 (mesylate) 169939-93-9 (HCl)
Molecular Weight (MW)	505.01
Formula	C28H28N4O3.HCl
CAS No.	169939-93-9 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 50 mg/mL (99.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (12E, 32E, 7S)-7-((dimethylamino)methyl)-22, 25-dihydro-11H, 21H, 31H-6-oxa-1, 3(3, 1)-diindola-2(3, 4)-pyrrolacyclononaphane-22, 25-dione hydrochloride InChi Key: NYQIEYDJYFVLPO-FERBBOLQSA-N InChi Code: InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24; /h3-10, 16-18H, 11-15H2, 1-2H3, (H, 29, 33, 34); 1H/t18-; /m0./s1 SMILES Code: O=C1NC(C2=C1C3=CN(C4=CC=CC=C34)CC[CH](CN(C)C)OCCN5C=C2C6=CC=CC=C56)=O.[H]Cl
Synonyms	Ruboxistaurin, LY333531 hydrochloride; LY-333531 hydrochloride; LY 333531 hydrochloride

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer