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Silmitasertib (CX-4945) Sodium

Silmitasertib (CX-4945) Sodium

Item no.	V2616-500mg
Manufacturer	InvivoChem LLC
CASRN	1309357-15-0
Amount	500 mg
Quantity options	100 mg 10 mg 1 mg 250 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2616CAS #:1309357-15-0Purity >=98% Description: Silmitasertib (also know as CX-4945) is a selective and orally bioavailable small-molecule inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, it is less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). CX-4945 selectively binds to and inhibits the enzyme casein kinase II (CK2), which may lead to an inhibition of cellular proliferation. CK2 is a protein kinase overexpressed in a variety of cancer cell types and is correlated with malignant transformation, tumor growth and survival. Description:SilmitasertibCX-4945 References: Cancer Res. 2010 Dec 15; 70(24):10288-98; J Med Chem. 2011 Jan 27; 54(2):635-54. References: Related CAS: 1009820-21-6 (free acid)
Molecular Weight (MW)	371.75
Formula	C19H11ClN3O2 Na
CAS No.	1309357-15-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Other info	Chemical Name: Sodium 5-[(3-Chlorophenyl)amino]-benzo[c]-2, 6-naphthyridine-8-carboxylate InChi Key: ODDAAPQSODILSN-UHFFFAOYSA-M InChi Code: InChI=1S/C19H12ClN3O2.Na/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18; /h1-10H, (H, 22, 23)(H, 24, 25); /q; +1/p-1 SMILES Code: O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)[O-].[Na+]
Synonyms	CX-4945; CX 4945; CX4945 Sodium Salt

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Amount: 500 mg

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Delivery expected until 11/6/2025

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