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Isatin (Indoline-2,3-dione)

Isatin (Indoline-2,3-dione)

Item no.	V2630-50g
Manufacturer	InvivoChem LLC
CASRN	91-56-5
Amount	50 g
Quantity options	100 g 10 g 200 g 25 g 2 g 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2630CAS #:91-56-5Purity >=98% Description: Isatin (also named 2, 3-Indolinedione) is an endogenous MAO inhibitor. Isatin induces apoptosis of MCF-7 cells. Bcl-2 expression is decreased and the ratio of Bcl-2 to Bax is significantly decreased by isatin. The mitochondrial transmembrane potential is markedly decreased and the release of cytochrome c into the cytosol is elevated following treatment with isatin. At the same time, caspase-9 and -3 are stimulated, followed by the degradation of ICAD, a caspase-3 substrate. References: Neurochem Int. 2005 Aug; 47(3):216-24; Neurotoxicology. 2004 Jan; 25(1-2):205-13.
Molecular Weight (MW)	147.13
Formula	C8H5NO2
CAS No.	91-56-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 29 mg/mL (197.1 mM)
	Water: < 1 mg/mL
	Ethanol: 10 mg/mL (68 mM)
Solubility (In vivo)	Chemical Name: indoline-2, 3-dione InChi Key: JXDYKVIHCLTXOP-UHFFFAOYSA-N InChi Code: InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H, (H, 9, 10, 11) SMILES Code: O=C1NC2=C(C=CC=C2)C1=O
Synonyms	2, 3-Indolinedione ; Isatin; 2, 3-Dioxo-2, 3-dihydroindole; Isatic acid lactam; Isotin

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