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Sivelestat sodium

Sivelestat sodium

Item no.	V2636-250mg
Manufacturer	InvivoChem LLC
CASRN	150374-95-1
Amount	250 mg
Quantity options	100 mg 10 mg 1 g 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2636CAS #:150374-95-1 Purity >=98% Description: Sivelestat sodium, the sodium salt of Sivelestat (also known as ONO5046; LY544349; EI546), is a novel, potent and competitive inhibitor of human neutrophil elastase (HNE) with IC50 value of 44 nM and Ki of 200 nM; it also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster by intratracheal administration and increase of skin capillary permeability in guinea pig by intravenous administration. It is used in the treatment of acute respiratory failure. Preliminary studies show Sivelestat may also improve neuropathic pain. References: Interact Cardiovasc Thorac Surg. 2008 Oct; 7(5):785-8; Dig Dis Sci. 2014 Apr; 59(4):787-94. Related CAS#:201677-61-4 (Sivelestat sodium tetrahydrate); 127373-66-4 (free acid)
Molecular Weight (MW)	456.44
Formula	C??H??N?NaO?S
CAS No.	150374-95-1 (sodium salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (189.2 mM)
	Water: N/A
	Ethanol: N/A
SMILES	[O-]C(CNC(C1=CC=CC=C1NS(C2=CC=C(OC(C(C)(C)C)=O)C=C2)(=O)=O)=O)=O.[Na+]
Synonyms	Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium; ONO5046, LY544349, EI546; ONO 5046; ONO5046; ONO-5046; LY544349; LY-544349; LY 544349; EI 546 sodium salt hydrate, Elaspol sodium salt hydrate, LY 544349 sodium salt hydrate, Trade name: Elaspol.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 9/4/2025

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