« Back
Home /
NVP-CGM097

NVP-CGM097

Item no.	V2654-25mg
Manufacturer	InvivoChem LLC
CASRN	1313363-54-0
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2654CAS #:1313363-54-0Purity >=98% Description: NVP-CGM097 (also known as CGM-097, CGM 097, CGM 097, NVP CGM097) is a novel, highly potent, orally bioavailable and selective MDM2 ( (human homolog of double minute 2) inhibitor with IC50 of 1.7+/-0.1 nM for hMDM2 and with anticancer activity. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. Description: References: J Med Chem. 2015 Aug 27; 58(16):6348-58; Neuroendocrinology. 2016 Nov 21. References: Related CAS#:1313367-56-4 (NVP-CGM097 sulfate)
Molecular Weight (MW)	659.26
Formula	C38H47ClN4O4
CAS No.	1313363-54-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 65 mg/mL (98.6 mM)
	Water: < 1 mg/mL
	Ethanol: 65 mg/mL (98.6 mM)
Other info	Chemical Name: (S)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r, 4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1, 2-dihydroisoquinolin-3(4H)-one InChi Key: CLRSLRWKONPSRQ-IIPSPAQQSA-N InChi Code: InChI=1S/C38H47ClN4O4/c1-25(2)47-35-22-33-28(20-34(35)46-5)21-36(44)43(38(33)27-8-10-29(39)11-9-27)32-16-14-30(15-17-32)41(4)23-26-6-12-31(13-7-26)42-19-18-40(3)37(45)24-42/h8-11, 14-17, 20, 22, 25-26, 31, 38H, 6-7, 12-13, 18-19, 21, 23-24H2, 1-5H3/t26-, 31-, 38-/m0/s1 SMILES Code: O=C1N(C2=CC=C(N(C)C[CH]3CC[CH](N4CC(N(C)CC4)=O)CC3)C=C2)[CH](C5=CC=C(Cl)C=C5)C6=C(C=C(OC)C(OC(C)C)=C6)C1
Synonyms	CGM-097, CGM 097, CGM 097, NVP CGM097; CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097; NVP CGM097; NVP CGM 097; NVP CGM-097.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 25 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 15 days

Compare

Add to wishlist

Get an offer