BI-78D3

Description: BI-78D3 (also known as JNK Inhibitor X) is a novel, potent and competitive JNK inhibitor with IC50 of 280nM. It displays > 100 fold selectivity over p38alpha and no activity at mTOR and PI-3K. BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation. In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes. BI-78D3 dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell. BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes.

References: Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13; Oncotarget. 2012 Oct; 3(10):1169-81.

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