LF3

Item no.	V2725-100mg
Manufacturer	InvivoChem LLC
CASRN	664969-54-4
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2725CAS #:664969-54-4Purity >=98% Description: LF3 is a specific antagonist of the beta-Catenin/TCF4 interaction with antitumor activity; it acts by disrupting the interaction between beta-catenin and TCF4 with an IC50 of 1.65 uM. LF3 does not cause cell death or interfere with cadherin-mediated cell-cell adhesion. The self-renewal capacity of cancer stem cells is blocked by LF3 in concentration-dependent manners, as examined by sphere formation of colon and head and neck cancer stem cells under nonadherent conditions. LF3 inhibits Wnt/beta-catenin signaling, but does not interfere with E-cadherin/beta-catenin-mediated cell-cell adhesion. References: Cancer Res. 2016 Feb 15; 76(4):891-901.
Molecular Weight (MW)	416.56
Formula	C20H24N4O2S2
CAS No.	664969-54-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 83 mg/mL (199.3 mM)
	Water: < 1 mg/mL
	Ethanol: 5 mg/mL (12.0 mM)
SMILES Code	S=C(N1CCN(C/C=C/C2=CC=CC=C2)CC1)NC3=CC=C(S(=O)(N)=O)C=C3
Synonyms	LF-3; LF 3

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Amount: 100 mg

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