Dichloroacetate

Description: Dichloroacetate (CPC-211; DCA; X-11S) is a potent and specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 uM for PDK2 and PDK4 respectively. It has the potential for the treatment of myocardia ischemia. Dichloroacetate has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth. DCA can trigger apoptosis of human lung, breast and brain cancer cells. After DCA treatment, cancer cells shows increased levels of ROS, depolarization of the MMP in vitro and increased apoptosis both in vitro and in vivo.

References: World J Clin Cases. 2016 Oct 16; 4(10):336-343; Mol Cancer. 2011 Nov 18; 10:142.