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Verubecestat (MK-8931)

Verubecestat (MK-8931)

Item no.	V2792-50mg
Manufacturer	InvivoChem LLC
CASRN	1286770-55-5
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2792CAS #:1286770-55-5 Purity >=98% Description: MK-8931 (also known as Verubecestat or SCH 900931) is a beta-secretase 1 and BACE1 inhibitor that is in Phase 3 clinical trial for treatment of Alzheimer's disease. Amyloidogenic pathway in Alzheimer's disease (AD) involves breakdown of APP by beta-secretase followed by gamma-secretase and results in formation of amyloid beta plaque. beta-secretase has been a promising target for developing novel anti-Alzheimer drugs.MK-8931 binds significantly to beta-secretase. target: BACE1. In vitro:MK-8931 can effectively reduce Abeta40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. Docking revealed that, with respect to their free binding energy, acylguanidine 7a has the lowest binding energy followed by MK-8931 and pioglitazone and binds significantly to beta-secretase. References: Transl Neurodegener. 2016 Jul 14; 5:13; Adv Bioinformatics. 2016; 2016:9258578. Related CAS#:1875153-95-9 (Tosylate); 1970144-54-7 (HBr); 1897370-45-4 (hydrate); 2095432-65-6 (TFA)
Molecular Weight (MW)	409.41
Formula	C17H17F2N5O3S
CAS No.	1286770-55-5 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 81 mg/mL (154.74 mM)
	Water: < 1 mg/mL
	Ethanol: 2 mg/mL (3.82 mM)
SMILES	O=C(NC1=CC=C(F)C([C](C2)(C)N=C(N)N(C)S2(=O)=O)=C1)C3=NC=C(F)C=C3
Synonyms	MK-8931; MK 8931; MK8931; MK-8931-009; SCH 900931; SCH-900931; SCH900931

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Amount: 50 mg

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