8-Nitrotryptanthrin

Description: 8-Nitrotryptanthrin is a potent selective inhibitor of the human indoleamine 2, 3-dioxygenase 2 (hIDO2) which dramatically reduces IDO2 activity with Ki value of 0.97 uM. As an analogue of IDO1 (indoleamine 2, 3-dioxygenase 1), the well-known new therapeutic target, IDO2 is receiving increased attention for its potential therapeutic applications. The typtanthrin derivative 8-Nitrotryptanthrin is found to be a potent hIDO2 inhibitor with superior efficiency much better than that of the most frequently-used inhibitor L-1-MT. 8-Nitrotryptanthrin has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 ug/mL. 8-Nitrotryptanthrin also has a LORA MIC value of 2.4 ug/mL, while the majority of analogues lack LORA activity.

References: J Nat Prod. 2013 Mar 22; 76(3):354-67; Eur J Med Chem. 2016 Nov 10; 123:171-179.