NS6180

Item no.	V2816-250mg
Manufacturer	InvivoChem LLC
CASRN	353262-04-1
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2816CAS #:353262-04-1Purity >=98% Description: NS6180 is a novel potent and selective KCa3.1 channel inhibitor with IC50 of 9 nM. KCa3.1 channels are targets for pharmacological control of intestinal inflammation. NS6180 prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. NS6180 inhibited cloned human KCa3.1 channels via T250 and V275, the same amino acid residues conferring sensitivity to triarylmethanes such as like TRAM-34. NS6180 inhibited endogenously expressed KCa3.1 channels in human, mouse and rat erythrocytes, with similar potencies (15–20 nM). References: Br J Pharmacol. 2013 Jan; 168(2):432-44.
Molecular Weight (MW)	323.33
Formula	C??H??F?NOS
CAS No.	353262-04-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 47 mg/mL
	Water: < 1mg/mL
	Ethanol: < 1mg/mL
Solubility (In vivo)	O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3
Synonyms	NS6180; NS-6180; NS 6180.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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