ML385

Item no.	V2828-100mg
Manufacturer	InvivoChem LLC
CASRN	846557-71-9
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2828CAS #:846557-71-9Purity >=98% Description:ML-385 is a novel, potent and selective NRF2 inhibitor (Nrf2: nuclear factor E2 related factor 2) with an IC50 of 1.9 uM. ML385 interacts with NRF2 and affects the DNA binding activity of the NRF2-MAFG protein complex. The addition of ML385 decreases anisotropy dose-dependently. ML-385 selectively intervenes therapeutic resistance in KEAP1-Deficient NSCLC Tumors. It acts by inhibiting the downstream target gene expression of NRF2. ML385 in combination with chemotherapeutic agents such as carboplatin showed significant tumor-suppression activity. References: ACS Chem Biol. 2016 Nov 18; 11(11):3214-3225. Epub 2016 Oct 17.
Molecular Weight (MW)	511.60
Formula	C29H25N3O4S
CAS No.	846557-71-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 30 mg/mL
	Water: N/A
	Ethanol: N/A
SMILES	O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
Synonyms	ML385; ML 385; ML-385 Exact Mass: 511.1566 Chemical Name: N-[4-[2, 3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1, 3-benzodioxole-5-acetamide

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Amount: 100 mg

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