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Eleclazine HCl

Eleclazine HCl

Item no.	V2846-5mg
Manufacturer	InvivoChem LLC
CASRN	1448754-43-5
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 2 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2846CAS #:1448754-43-5Purity >=98% Description: Eleclazine hydrochloride (also known as GS-6615) is a novel late Na+ current inhibitor with IC50 value of 0.7 uM. Enhanced late Na+ current (late INa ) in the myocardium is pro-arrhythmic. Inhibition of this current is a promising strategy to stabilize ventricular repolarization and suppress arrhythmias. Eleclazine was a selective inhibitor of late INa , stabilizes the ventricular repolarization and suppresses arrhythmias in a model of LQT3. The concentrations at which the electrophysiological effects of Eleclazine were observed are comparable to plasma levels associated with QTc shortening in patients with LQT3, indicating that these effects are clinically relevant. Eleclazine is currently in clinical development for the treatment of long QT syndrome 3 (LQT3). References: Br J Pharmacol. 2016 Nov; 173(21):3088-3098; Heart Rhythm. 2016 Sep; 13(9):1860-7. Related CAS#: 1443211-72-0 (free base)
Molecular Weight (MW)	451.83
Formula	C??H??ClF?N?O?
CAS No.	1448754-43-5 HCI
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1 mg/mL
	Ethanol:
SMILES Code	O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl
Synonyms	GS-6615 HCl; GS 6615 HCl; GS6615 HCl; Eleclazine HCl

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Amount: 5 mg

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