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Bimiralisib (PQR309)

Bimiralisib (PQR309)

Item no.	V2864-100mg
Manufacturer	InvivoChem LLC
CASRN	1225037-39-7
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2864CAS #:1225037-39-7Purity >=98% Description: Bimiralisib (also known as PQR-309; PI3K-IN-2) is an orally bioavailable, brain-penetrant, and balanced pan-inhibitor of PI3K/mTOR (phosphoinositide-3-kinase/mammalian target of rapamycin) with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kalpha, PI3Kdelta, PI3Kbeta, PI3Kgamma and mTOR, respectively. Bimiralisib has potential antineoplastic activity and is orally bioavailable, is able to cross the blood-brain barrier, and displayed favorable pharmacokinetic parameters in mice, rats, and dogs. Bimiralisib demonstrated efficiency in inhibiting proliferation in tumor cell lines and a rat xenograft model. Bimiralisib has a broad application range in oncology, including treatment of brain tumors or CNS metastasis. Bimiralisib is currently in phase II clinical trials for advanced solid tumors and refractory lymphoma. References: J Med Chem. 2017 Sep 14; 60(17):7524-7538; Eur J Cancer. 2018 Jun; 96:6-16. Related CAS#: 1820902-72-4 (HCl salt)' 1225037-39-7 (free base)
Molecular Weight (MW)	411.38
Formula	C17H20F3N7O2
CAS No.	1225037-39-7(free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: N/A
	Ethanol: N/A
SMILES Code	NC1=NC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C(C(F)(F)F)=C1
Synonyms	Bimiralisib; PQR309; PQR-309; PQR309; PI3K-IN-2; PI3K IN-2

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Amount: 100 mg

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Delivery expected until 11/6/2025

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