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Clemizole hydrochloride

Clemizole hydrochloride

Item no.	V2868-100mg
Manufacturer	InvivoChem LLC
CASRN	1163-36-6
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2868CAS #:Purity >=98% Description: Clemizole hydrochloride (also known as AL 20 HCl, P 48 HCl, and/or Reactrol), is a potent inhibitor of transient receptor potential channel TRPC5 (Canonical transient receptor potential channel 5) and also an H1 histamine receptor antagonist. It is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24+/-1 nM, whereas its EC50 for viral replication is 8 uM. Clemizole efficiently blocks TRPC5 currents and Ca(2+) entry in the low micromolar range (IC50 = 1.0-1.3 uM). Clemizole was not only effective in blocking heterologously expressed TRPC5 homomers but also TRPC1:TRPC5 heteromers as well as native TRPC5-like currents in the U-87 glioblastoma cell line. References: Nat Biotechnol. 2008 Sep; 26(9):1019-27; Mol Pharmacol. 2014 Nov; 86(5):514-21. Related CAS#:442-52-4 (free base)
Molecular Weight (MW)	361.11
Formula	C19H21Cl2N3
CAS No.	1163-36-6 (HCl salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 3.6 mg/mL
	Water: < 1 mg/mL
	Ethanol:
SMILES Code	ClC1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CN4CCCC4.[H]Cl
Synonyms	Clemizole Hydrochloride; Clemizole HCl; AL 20 HCl; AL20 HCl; AL-20 HCl; P 48 HCl; Reactrol HCl

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Amount: 100 mg

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