S0859

Item no.	V2877-500mg
Manufacturer	InvivoChem LLC
CASRN	1019331-10-2
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2877CAS #:1019331-10-2Purity >=98% Description: S0859, an N-cyanosulphonamide compound, is a novel, selective, high-affinity generic inhibitor of NBC (Na(+)-coupled HCO(3)(-) transporters, it is potentially important for probing the transporter's functional role in heart and other tissues. S0859 reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). In HEPES-buffered superfusates, NHE-mediated pH(i) recovery was unaffected by 30 microM S0859. With CO(2)/HCO(3) (-) buffer, pH(i) recovery from intracellular alkalosis (mediated by Cl(-)/HCO(3) (-) and Cl(-)/OH(-) exchange) was also unaffected. The time course of recovery of pH(i) and contraction was slowed by S0859, confirming that NBC is a significant controller of contractility during acidosis. References: Br J Pharmacol. 2008 Mar; 153(5):972-82; ChemMedChem. 2012 Oct; 7(10):1808-14.
Molecular Weight (MW)	530.04
Formula	C29H24ClN3O3S
CAS No.	1019331-10-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water:
	Ethanol:
SMILES Code	O=C(N(CC1=CC=C(C2=CC=CC=C2S(=O)(NC#N)=O)C=C1)CC3=CC=C(C)C=C3)C4=CC=CC=C4Cl
Synonyms	S-0859; S 0859; S0859.

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