HA15

Item no.	V2891-50mg
Manufacturer	InvivoChem LLC
CASRN	1609402-14-3
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2891CAS #:1609402-14-3Purity >=98% Description: HA15 specifically targets chaperone BiP/GRP78/HSPA5. HA15 induces ER stress leading to cancer cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. HA15 displayed activity against other liquid and solid tumors. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. References: Cancer Cell. 2016 Jun 13; 29(6):805-819.
Molecular Weight (MW)	466.58
Formula	C23H22N4O3S2
CAS No.	1609402-14-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES Code	CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O
Synonyms	HA15; HA-15; HA 15

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Amount: 50 mg

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