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Lu AE58054 hydrochloride

Lu AE58054 hydrochloride

Item no.	V2927-500mg
Manufacturer	InvivoChem LLC
CASRN	467458-02-2
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2927CAS #:467458-02-2 Purity >=98% Description: Lu AE58054 hydrochloride (also known as Idalopirdine hydrochloride) is potent and selective antagonist of the 5-HT(6) receptor with Ki value of 0.83 nM. In a 5-HT(6) GTPgammaS efficacy assay, Lu AE58054 showed no agonist activity, but demonstrated potent inhibition of 5-HT-mediated activation. Besides medium affinity to adrenergic alpha(1A)- and alpha(1B)-adrenoreceptors, Lu AE58054 demonstrated > 50-fold selectivity for more than 70 targets examined. Lu AE58054 is in phase III clinical trials as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. Description: References: Int J Neuropsychopharmacol. 2010 Sep; 13(8):1021-33. References: Related CAS#:467459-31-0 (free base)
Molecular Weight (MW)	434.83
Formula	C20H20ClF5N2O
CAS No.	467458-02-2 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol:
SMILES Code	FC1=CC(NC=C2CCNCC3=CC(OCC(F)(F)C(F)F)=CC=C3)=C2C=C1.Cl
Synonyms	Lu AE58054 Hydrochloride; Idalopirdine Hydrochloride

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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