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ETC159 (ETC192215)

ETC159 (ETC192215)

Item no.	V2938-500mg
Manufacturer	InvivoChem LLC
CASRN	1638250-96-0
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2938CAS #:1638250-96-0Purity >=98% Description: ETC-159 (ETC-192215) is a novel, potent and orally bioavailable PORCN inhibitor which inhibits beta-catenin reporter activity with an IC50 of 2.9 nM and blocks the secretion and activity of all Wnts. ETC-159 has robust activity in multiple cancer models driven by high Wnt signaling. ETC-159 is highly efficacious in molecularly defined colorectal cancers (CRCs) with R-spondin translocations. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Description: References: Oncogene. 2016 Apr 28; 35(17):2197-207. References:
Molecular Weight (MW)	391.38
Formula	C19H17N7O3
CAS No.	1638250-96-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 34 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	O=C1C2C(N=CN2C(CNC3=CC=C(C4=CC=CC=C4)N=N3)=O)N(C)C(N1C)=O
Synonyms	ETC-1922159; ETC 1922159; ETC1922159; ETC-159; ETC159; ETC 159

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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Delivery expected until 10/2/2025

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