ML348

Item no.	V2945-50mg
Manufacturer	InvivoChem LLC
CASRN	899713-86-1
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2945CAS #:899713-86-1Purity >=98% Description: ML348 (also known as CID 3238952; SID 160654487) is a reversible inhibitor of LYPLA1 (Lysophospholipase 1) with an IC50 value of 210 nM. It exhibits 14-fold selectivity for LYPLA1 over LYPLA2, ML348 is also selective over a panel of ca.30 other serine hydrolases. Protein palmitoylation is an essential post-translational modification necessary for trafficking and localization of regulatory proteins that play key roles in cell growth and signaling. Multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation. LYPLA1 has been identified as a candidate protein palmitoyl thioesterase responsible for HRAS depalmitoylation in mammalian cells. Description: References: Oncotarget. 2016 Feb 9; 7(6):7297-306; https://www.ncbi.nlm.nih.gov/pubmed/24624465 References:
Molecular Weight (MW)	415.79
Formula	C18H17ClF3N3O3
CAS No.	899713-86-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol: N/A
SMILES Code	O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2
Synonyms	CID 3238952; SID 160654487; ML348; ML-348; ML 348; GNF-Pf-1127; GNF Pf-1127; GNF-Pf 1127

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