« Back
Home /
SIS3 HCl

SIS3 HCl

Item no.	V2956-250mg
Manufacturer	InvivoChem LLC
CASRN	521984-48-5
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2956CAS #:521984-48-5Purity >=98% Description: SIS3 HCl is a potent and selective inhibitor of Smad3 which is a receptor-regulated intracellular protein that functions downstream of TGF-beta and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. SIS3 can block excessive ECM production from the TGF-beta1-treated normal fibroblasts and scleroderma fibroblasts, the model of cells with autocrine TGF-beta signaling in vitro. Addition of SIS3 attenuates the effects of TGF-beta1 by reducing the transcriptional activity. SIS3 also inhibits the myofibroblast differentiation of fibroblasts by TGF-beta1. Description: References: Mol Pharmacol. 2006 Feb; 69(2):597-607. Epub 2005 Nov 15. References: Related CAS#: 1009104-85-1 (free base); 521984-48-5 (HCl)
Molecular Weight (MW)	489.99
Formula	C28H27N3O3.HCl
CAS No.	521984-48-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 97 mg/mL (197.96 mM)
	Water: < 1 mg/mL
	Ethanol: 24 mg/mL (48.98 mM)
SMILES	O=C(N1CC2=C(C=C(OC)C(OC)=C2)CC1)/C=C/C3=C(C4=CC=CC=C4)N(C)C5=NC=CC=C53.[H]Cl
Synonyms	SIS 3; SIS-3; SIS3; SIS 3 HCl; SIS-3 HCl; SIS3 HCl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer